We modelled the ability of pathways activated by tyrosine kinase receptors to induce GBM formation in mice with the RCAS/tv-a system, which allows post-natal gene transfer in a cell-type–specific ...
New work shows that activation of the Ras guanine nucleotide exchange factor SOS is dependent upon the membrane density of phosphatidylinositol-4,5-bisphosphate (PIP 2) and GTP-bound Ras. These ...
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