If our genes are so similar, what really makes a eukaryote different from a prokaryote, or a human from E. coli? The answer lies in the difference in gene expression and regulation used. Regulation of ...

Alternative splicing is a genetic process where different segments of genes are removed, and the remaining pieces are joined together during transcription to messenger RNA (mRNA). This mechanism ...

Cyclone is a portable gene-switch system that uses acyclovir to reversibly control gene expression with minimal toxicity.

Data showed that the expression (activity) of the ABCA3 gene was lower in IPAH patients, while that of the SMAD9 gene was ...

To help achieve more precise control of gene therapy, engineers have designed a new control circuit that can keep gene expression levels within a target range. The method could be used to deliver ...

This framework enables quantitative predictions about how cellular systems convert frequency-encoded signals into precise amplitude outputs across different dynamical regimes.

Researchers at the Jackson Laboratory (JAX), the Broad Institute of MIT and Harvard, and Yale University, have used artificial intelligence (AI) to design thousands of new DNA switches that can ...

A collaborative effort has shed valuable light on how monoamine neurotransmitters such as serotonin, dopamine, and now histamine help regulate brain physiology and behavior through chemical bonding of ...

Investigators at Weill Cornell Medicine have developed a versatile and non-toxic technology for controlling the activity of ...

Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the immune system.

Researchers have discovered that a gene called CHRNA3 plays a key role in determining alcohol sensitivity, helping explain why some people tolerate alcohol better than others.