A causative role for Notch signalling is well established in T cell acute lymphoblastic leukaemias (T-ALLs), which have activating mutations in the Notch genes resulting in a constitutively active ...
Notch signalling can be either oncogenic or tumour suppressive depending on the tissue and/or cellular context. Notch signalling is tumour suppressive for various solid tumours, including squamous ...
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