RNA interference using small interfering RNAs (siRNAs) has become a mainstay of functional gene characterization and has ...

The Tas protein uses an RNA guide to recognize a specific target DNA sequence. A vast search of natural diversity has led scientists at MIT’s McGovern Institute and the Broad Institute of MIT and ...

Even without deep computational skills, scientists can use the CRISPRware program to quickly browse entire libraries of precomputed guide RNAs for six model organisms, zoom in on their gene or region ...

Ribonucleic acid, also called RNA, is a molecule present in all living cells. It plays a critical role in transmitting genetic instructions from DNA and creating proteins. With the power to execute a ...

In modern functional genomics, understanding how specific genes control cellular behavior requires both targeted intervention and high-resolution analysis. That’s where Perturb-Seq comes in—a method ...

The interior of a cell is packed with proteins and nucleic acids, such as RNA, all of which need to perform specific functions at the exact right time. If they don't, serious diseases—ALS, ...

Scientists have transformed RNA, a biological molecule present in all living cells, into a biosensor that can detect tiny chemicals relevant to human health. Research by scientists centers on RNA, a ...