The research team developed a genetically engineered mouse model carrying a mutation (E3896A) in RyR1, which disrupts its calcium-binding site, effectively disabling CICR while preserving ...

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

BOULDER, Colo.--(BUSINESS WIRE)--Edgewise Therapeutics, Inc., (Nasdaq: EWTX), a clinical-stage biopharmaceutical company focused on developing orally bioavailable, targeted, small molecule therapies ...

This is a preview. Log in through your library . Abstract Particular thiols of the myosin subfragment 1 moieties of single glycerinated muscle fibers are covalently labeled with rhodamine. By using ...

THE myosin crossbridges which project from the thick filaments of striated muscle are known to bend and attach to the thin filaments in the absence of their enzymatic substrate, ATP 1. Huxley and ...

Using powerful new visualization technologies, researchers have captured the first 3-D images of the structure of a key muscle receptor, providing new insights on how muscles develop across the animal ...

Numerous motor and structural proteins compose a highly ordered structure known as the sarcomere, the basic unit of muscle contraction in heart and skeletal muscles. Sarcomeric myosin heavy chain ...

In sports, it is common practice to apply ice to sore muscles in order to reduce inflammation. However, a new study on mice has revealed that icing severe muscle injuries may actually prolong the ...